Pharmacological aspects of mammalian hibernation. Central thermoregulation factors in hibernation cycle.
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چکیده
منابع مشابه
Hibernation in noncontracting mammalian cardiomyocytes.
BACKGROUND -The aim of the present study was to establish whether isolated neonatal mammalian cardiomyocytes were capable of downregulating energy-using processes other than contraction while maintaining metabolic stability when oxygen availability was reduced. METHODS AND RESULTS Metabolic response of cardiomyocytes was investigated under moderate (5 to 6 micromol/L) and severe (2 to 3 micro...
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متن کاملMammalian Hibernation: Biochemical Adaptation and Gene Expression
The core body temperature (Tb) of most mammals is maintained remarkably constant (typically 36 to 388C, depending on the species), regulated by a thermostat in the hypothalamus of the brain and with heating and cooling achieved, as needed, by a variety of physiological and biochemical mechanisms. All mammals, including humans, are endotherms (generating internal heat by metabolic reactions) and...
متن کاملHibernation
Hibernation (multiday torpor) and daily torpor in heterothermic mammals and birds are characterized by pronounced temporal reductions in body temperature, energy expenditure, water loss, and other physiological functions and are the most effective means for energy conservation available to endotherms. Hibernators express multiday torpor predominately throughout winter, which substantially enhan...
متن کاملMetabolic suppression in mammalian hibernation: the role of mitochondria.
Hibernation evolved in some small mammals that live in cold environments, presumably to conserve energy when food supplies are low. Throughout the winter, hibernators cycle spontaneously between torpor, with low metabolism and near-freezing body temperatures, and euthermia, with high metabolism and body temperatures near 37°C. Understanding the mechanisms underlying this natural model of extrem...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2000
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.116.304